My favorite kind of article. Glad to know there are folks out there thinking the same as me.
I would still consider using something like Markup (https://markup.beforesemicolon.com) or jQuery to handle DOM and reactiveness.
Although modern Web API has gotten better, DOM manipulation will eventually slow you down and development speed matters so you dont constantly find yourself reinventing the wheel.
Considering small and fast libraries like these that further extend Web APIs to simplify things while still allowing you to follow Web Standards and move fast makes a huge difference.
Thanks for this